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Fractyl also has a clinical trial application pending in Australia

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This is because they can facilitate glucose breakdown, i.e., increase glycolysis (the production of new glucose), thereby successfully regulating blood glucose levels

A network meta-analysis of 22 RCTs covering 2,258 participants found GLP-1 receptor agonists reduced lean mass by a mean of 0.86 kg, with lean mass comprising roughly 25% of total weight lost across agents